POLICE are investigating reports of a shooting in relation to a double fatality on the Pacific Highway on Sunday night.

About 7.45pm on Sunday night emergency services were called to an incident south of Grafton near Gelnugie after a vehicle, which was was travelling south on the Pacific Highway, Glenugie, left the road, crashed through a fence, and rolled.

Coffs/Clarence Police District crime manager manager Detective Senior Sergeant Peter O'Reilly confirmed 42-year-old Grafton man Daniel Elliott and 29-year-old Tucabia man Jared Ward were found deceased at the scene, while a female was trapped in the car for a short period of time before she was removed from the vehicle and conveyed to Gold Coast University Hospital in a serious condition.

"Police received information at the scene that the vehicle may have been involved in a shooting and that's certainly a part of our investigation at this time," Sgt O'Reilly said.

"There's nothing apparent at this stage but the vehicle is still in situ at the side of the road in a very difficult location so it's part of our investigation at this time."

Sgt O'Reilly refused to comment on whether the deceased were known to police.

With contra flow traffic controls still in place on the highway at the scene of the incident, Sgt O'Reilly said anyone with any information should come forward to Coffs/Clarence Police or Crime Stoppers.

"We're aware this is on the Pacific Highway and that there would be a lot of vehicles in the area at the time and certainly vehicles may have stopped to assist so we're seeking assistance from anybody that may have been in the area at the time or may have dash-cam footage to contact police or Crime Stoppers and assist us with our investigation," Sgt O'Reilly said.

Anyone with information about this incident is urged to contact Crime Stoppers: 1800 333 000 or https://nsw.crimestoppers.com.au. Information is treated in strict confidence. The public is reminded not to report crime via NSW Police social media pages.